abstract：:Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sue TK,Jaques LB,Yuen E

更新日期：1976-08-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:The intramuscular injection of aminooxyacetic acid (AOAA) into mice elevated the concentration of gamma-aminobutyric acid (GABA) in the brain, inhibited glutamic acid decarboxylase activity and delayed the onset of isonicotinic acid hydrazide induced seizures. Analyses of these results and of those obtained previously...

journal_title：Canadian journal of physiology and pharmacology

authors： Wood JD,Peesker SJ

更新日期：1976-08-01 00:00:00

abstract：:Infusion of glucose alone or glucose with insulin in cats subjected to acute myocardial ischemia did not alter the hemodynamic response of the cats to coronary artery ligation. Furthermore, determination of myocardial creatine phosphokinase (CPK) (ATP:creatine N-phosphotransferase, EC 2.7.3.2) activities failed to rev...

journal_title：Canadian journal of physiology and pharmacology

authors： Spath JA,Ogletree ML,Lefer AM

更新日期：1976-08-01 00:00:00

abstract：:Urinary output of Na+ and K+, and volume of urine have been studied in conscious, unrestrained, water-loaded male rats following the intraseptal injection of catecholamines. Natriuresis and kaliuresis increased after injecting noradrenaline (NA), the intensity being dose related. The dose-response curve suggests that ...

journal_title：Canadian journal of physiology and pharmacology

authors： Camargo LA,Saad WA,Netto CR,Gentil CG,Antunes-Rodrigues J,Covian MR

更新日期：1976-06-01 00:00:00

abstract：:The numbers and sizes of nerve fibres to the dorsal neck muscles, splenius, complexus and biventer cervicis have been examined in the cat. The total number of fibres is unusually high as is the content of sensory fibres (estimated as the loss of fibres after ganglionectomy). The fibre spectra of these sensory nerves h...

journal_title：Canadian journal of physiology and pharmacology

authors： Richmond FJ,Anstee GC,Sherwin EA,Abrahams VC

更新日期：1976-06-01 00:00:00

abstract：:Tissues from the duodenum and vas deferens of Sprague-Dawley rats were examined of the rat vas deferens and gap junctions. Can. J. Physiol. Pharmacol. 54, 412-416. by electron microscopy after glutaraldehyde fixation and postosmication. Gap junctions (nexuses) were readily demonstrated in the duodenum in both control ...

journal_title：Canadian journal of physiology and pharmacology

authors： Paton DM,Buckland-Nicks J,Johns A

更新日期：1976-06-01 00:00:00

abstract：:The cause of embryonic thyroidal enlargement in the progeny of chickens fed goitrogenic rapeseed meal (RSM) has been investigated. It has been found that eggs from birds fed RSM are low in iodine. The low concentration of iodine in the eggs of the goitrous birds is apparently due to diversion of a large proportion of ...

journal_title：Canadian journal of physiology and pharmacology

authors： March BE,Leung P

更新日期：1976-06-01 00:00:00

abstract：:The effect of 6-hydroxydopamine (6-OH-dopamine) and of a cholesterol rich diet on the plasma and aortic cholesterol of female rats were studied. Both the diet and the 6-OH-dopamine produced an important increase in plasmatic and aortic cholesterol. A synergistic effect of these two treatments was observed on the plasm...

journal_title：Canadian journal of physiology and pharmacology

authors： Lelorier J,Tremblay M,de Champlain J,Gattereau A,Davingnon J

更新日期：1976-04-01 00:00:00

abstract：:Ten minutes after KCl-depolarization of rat myometrial strips, at which time the muscles were in a state of sustained contracture, tissue levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were increased by approximately 40% over relaxed controls, and levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP...

journal_title：Canadian journal of physiology and pharmacology

authors： Diamond J,Holmes TG

更新日期：1975-12-01 00:00:00

abstract：:The anticonvulsant activity of delta9-tetrahydrocannabinol (delta9-THC) has been determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS) and in epileptic and nonepileptic chickens by Metrazol. Intravenous administration of the drug reduced both the severity and incidence of s...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnson DD,McNeill JR,Crawford RD,Wilcox WC

更新日期：1975-12-01 00:00:00

abstract：:The influence of drugs on ciliary beat frequency in the intrapulmonary airways of rats was studied in vitro. Sympathomimetic drugs significantly increased the ciliary beat frequency. Acetylcholine, pilocarpine, aminophylline, prednisolone, potassium iodide, and ammonium chloride also caused cilioexcitation, though to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Melville GN,Iravani J

更新日期：1975-12-01 00:00:00

abstract：:A study of the relationship between the mechanical response of human iliac arteries subjected to sinusoidally varying dynamic pressures superimposed on a static pressure of 100 mm Hg (1mm Hg = 133 N/m2) and the development of arterial dilatation, with particular reference to poststenotic dilatation has been conducted....

journal_title：Canadian journal of physiology and pharmacology

authors： Vito R,Tso WK,Schwartz CJ

更新日期：1975-12-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:Local microinjections of harmaline evoked sustained rhythmic activity in the inferior olive of decerebrate cats. Harmaline appears to exert its action within restricted areas of the inferior olivary complex: the caudal halves of the dorsal and medial accessory nuclei. Since the highly synchronized activity generated b...

journal_title：Canadian journal of physiology and pharmacology

authors： De Montigny C,Lamarre Y

更新日期：1975-10-01 00:00:00

abstract：:The metabolic and body weight changes in two non-pregnant beef cows were studied during prolonged exposure to warm (20 +/- 3 degrees C, relative humidity 50-70%) and cold (-10 +/- 2 or -25 +/- 4 degrees C) temperatures. Other factors including daily food intake were held constant throughout each 8-week exposure. Durin...

journal_title：Canadian journal of physiology and pharmacology

authors： Young BA

更新日期：1975-10-01 00:00:00

abstract：:Glucagon in small intravenous (i.v.) doses markedly increases glomerular filtration rate (GFR) in normal anesthetized dogs. In this study, the effects of glucagon 5 mug/min (i.v.) on renal hemodynamics was tested in four canine models of acute pre-renal failure (hemorrhage, barbiturate overdose; renal arterial clampin...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-08-01 00:00:00

abstract：:1. To examine whether different local anesthetics act on different or similar sites in the nerve membrane, the effects of combinations of lipid-soluble anesthetics and tetrodotoxin (TTX) were studied on the compound action potential of the frog sciatic nerve. 2. The nerve-blocking potency of TTX was potentiated 5-fold...

journal_title：Canadian journal of physiology and pharmacology

authors： Staiman AL,Seeman P

更新日期：1975-08-01 00:00:00

abstract：:A knowledge of the mechanical properties of valve tissue is a necessary prerequisite for a better understanding of valvular behavior and design of prosthetic heart valves. Elastic response of chordae tendineae under strain rates of 0.05 cm min(-1)(6.25% min(-1)) to 12.7 cm min(-1)(1600% min(-1)) were obtained by the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Lim KO,Boughner DR

更新日期：1975-06-01 00:00:00

abstract：:Experiments were done for indentification and localization of certain structural changes at different levels of jejunal villus of the hamster during positive and negative water transport across the intestine in vivo and in vitro. Positive transport occurred when the mucosal surface of the intestine was bathed (in vitr...

journal_title：Canadian journal of physiology and pharmacology

authors： Melligott TF,Beck IT,Dinda PK,Thompson S

更新日期：1975-06-01 00:00:00

abstract：:Our objective was to produce reductions in the luminal volume of Henle's loop and increases in linear flow velocity through the loop. We did this in a recollection micropuncture study by collecting fluid with and without suction from early distal tubules. With suction, transit time of fast green dye through the loop d...

journal_title：Canadian journal of physiology and pharmacology

authors： Baines AD,Wu CK

更新日期：1975-04-01 00:00:00

abstract：:Experiments were carried out in pigs to investigate the relationship between concentration of intestinal calcium-binding protein (CaBP) and the presence of rickets. Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs. The...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrison JE,Hitchman AJ,Brown RG

更新日期：1975-02-01 00:00:00

abstract：:The arterio--alveolar nitrogen difference (aADN2) has been associated in 27 normal adult subjects aged 20--60 years. As it may be assumed that venous and arterial PN2 are identical, we have used a sample of venous blood. There is a significant positive correlation between aADN2 and age. As the increase of aADN2 with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Corbet AJ,Ross JA,Beaudry PH

更新日期：1975-02-01 00:00:00

abstract：:Glucagon causes marked elevations of glomerular filtration rate (GFR) in dogs when administered intravenously (i.v.) in small doses. The associated natriuresis is thought to be entirely due to increments in the filtered sodium load. In this study, renal denervation, thyroparathyroidectomy, and blockade of cholinergic,...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-02-01 00:00:00